Dysplastic nevus - Displastični Nevus
☆ V rezultatih raziskave Stiftung Warentest iz Nemčije leta 2022 je bilo zadovoljstvo potrošnikov z ModelDermom le nekoliko nižje kot s plačanimi telemedicinskimi svetovanji.
Dysplastic nevi ― Zahodnjakom priporočamo biopsijo.
References
Dysplastic nevus , znan tudi kot atipični ali Clarkov nevus, je sprožil razprave v dermatologiji in dermatopatologiji. Zdravniki pogosto naredijo biopsijo teh madežev, ker so lahko videti nenormalno in vzbujajo zaskrbljenost glede melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi , znan tudi kot atipični ali Clarkov nevus, lahko včasih povzroči melanom. Približno 36 % melanomov najdemo v bližini displastičnih nevusov. Znaki, da se displastični nevus lahko spremeni v melanom, so neenakomerna oblika, več pigmentnih sprememb ali sivkasta barva. Ti raki se običajno pojavijo v mlajših letih (približno sredi tridesetih let) , lahko so večkratni in pogosto na trupu. Genetsko so dysplastic nevi vmes med benignimi nevusi in melanomom. Vendar samo 20 % do 30 % melanomov izvira iz obstoječih nevusov. Ker večina nevusov ne postane melanom, jih običajno ni priporočljivo preventivno odstraniti.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanom je vrsta tumorja, ki nastane, ko melanociti, celice, odgovorne za barvo kože, postanejo rakave. Melanociti izvirajo iz nevralnega grebena. To pomeni, da se melanomi lahko razvijejo ne samo na koži, temveč tudi na drugih področjih, kamor migrirajo celice živčnega grebena, kot so prebavila in možgani. Stopnja preživetja pri bolnikih z zgodnjim stadijem melanoma (stadij 0) je visoka in znaša 97 %, medtem ko se znatno zmanjša na približno 10 % pri tistih z diagnozo napredovalega stadija bolezni (stadij IV) .
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Tveganje za raka
Kot je razvidno iz belcev v Združenih državah Amerike, je tveganje za razvoj melanoma pri tistih z displastičnim nevusom v življenju večje od 10 %. Po drugi strani pa je pri tistih brez displastičnega nevusa tveganje za nastanek melanoma manjše od 1 %.
○ Previdnostni ukrepi za posameznike z displastičnimi nevusi
Samopregledovanje kože se običajno priporoča za preprečevanje melanoma (s prepoznavanjem atipičnih nevusov, ki jih je mogoče odstraniti) ali za zgodnje odkrivanje obstoječih tumorjev. Osebe z osebno ali družinsko anamnezo kožnega raka ali več atipičnih nevusov morajo obiskati dermatologa vsaj enkrat letno, da se prepričajo, da se ne razvija melanom.
Okrajšava [ABCDE] je bila uporabna za pomoč ponudnikom zdravstvenih storitev in laikom, da si zapomnijo ključne značilnosti melanoma. Na žalost za povprečnega človeka imajo lahko številne seboroične keratoze, nekateri lentigo senilis in celo bradavice značilnosti [ABCDE] in jih ni mogoče ločiti od melanoma.
○ [ABCDE]
Asymmetrical: Asimetrična kožna lezija.
Border: meja lezije je nepravilna.
Color: melanomi imajo običajno več nepravilnih barv.
Diameter: Nevusi, večji od 6 mm, so bolj verjetno melanomi kot manjši nevusi.
Evolution: Razvoj (tj. sprememba) nevusa ali lezije lahko pomeni, da lezija postaja maligna.